| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 15.10.21 21:00 | West Bromwich Albion | Birmingham City | 1:0 |
| 16.10.21 13:30 | FC Fulham | Queens Park Rangers | 4:1 |
| 16.10.21 16:00 | Blackburn Rovers | Coventry City | 2:2 |
| 16.10.21 16:00 | Bristol City | AFC Bournemouth | 0:2 |
| 16.10.21 16:00 | Huddersfield Town | Hull City A.F.C. | 2:0 |
| 16.10.21 16:00 | FC Middlesbrough | Peterborough United | 2:0 |
| 16.10.21 16:00 | FC Millwall | Luton Town | 0:2 |
| 16.10.21 16:00 | Nottingham Forest | FC Blackpool | 2:1 |
| 16.10.21 16:00 | Preston North End | Derby County | 0:0 |
| 16.10.21 16:00 | FC Reading | FC Barnsley | 1:0 |
| 16.10.21 16:00 | Sheffield United | FC Stoke City | 2:1 |
| 17.10.21 13:00 | Swansea City | Cardiff City | 3:0 |