| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 14.09.21 20:45 | Blackburn Rovers | Hull City A.F.C. | 2:0 |
| 14.09.21 20:45 | FC Blackpool | Huddersfield Town | 0:3 |
| 14.09.21 20:45 | AFC Bournemouth | Queens Park Rangers | 2:1 |
| 14.09.21 20:45 | Sheffield United | Preston North End | 2:2 |
| 14.09.21 21:00 | FC Reading | Peterborough United | 3:1 |
| 14.09.21 21:00 | West Bromwich Albion | Derby County | 0:0 |
| 15.09.21 20:45 | Coventry City | Cardiff City | 1:0 |
| 15.09.21 20:45 | Swansea City | FC Millwall | 0:0 |
| 15.09.21 20:45 | Birmingham City | FC Fulham | 1:4 |
| 15.09.21 20:45 | Bristol City | Luton Town | 1:1 |
| 15.09.21 20:45 | Nottingham Forest | FC Middlesbrough | 0:2 |
| 15.09.21 20:45 | FC Stoke City | FC Barnsley | 1:1 |