| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 24.09.21 20:45 | Coventry City | Peterborough United | 3:0 |
| 24.09.21 21:00 | West Bromwich Albion | Queens Park Rangers | 2:1 |
| 25.09.21 13:30 | FC Reading | FC Middlesbrough | 1:0 |
| 25.09.21 16:00 | Blackburn Rovers | Cardiff City | 5:1 |
| 25.09.21 16:00 | Swansea City | Huddersfield Town | 1:0 |
| 25.09.21 16:00 | FC Blackpool | FC Barnsley | 1:0 |
| 25.09.21 16:00 | AFC Bournemouth | Luton Town | 2:1 |
| 25.09.21 16:00 | Bristol City | FC Fulham | 1:1 |
| 25.09.21 16:00 | Nottingham Forest | FC Millwall | 1:1 |
| 25.09.21 16:00 | Sheffield United | Derby County | 1:0 |
| 25.09.21 16:00 | FC Stoke City | Hull City A.F.C. | 2:0 |
| 25.09.21 16:00 | Birmingham City | Preston North End | 0:0 |