| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 16.01.21 12:00 | UD Almeria | Deportivo Alaves | 5:0 |
| 16.01.21 12:00 | Deportiva Santa Eulalia del Rio | Real Valladolid | 1:4p.d. |
| 16.01.21 16:00 | FC Girona | FC Cadiz | 2:0 |
| 16.01.21 18:00 | CF Fuenlabrada | UD Levante | 3:5p.k. |
| 16.01.21 20:00 | CD Leganes | FC Sevilla | 0:1p.d. |
| 16.01.21 22:00 | Rayo Vallecano | FC Elche | 2:0 |
| 17.01.21 12:00 | FC Malaga | FC Granada | 1:2 |
| 17.01.21 12:00 | Espanyol Barcelona | CA Osasuna | 0:2 |
| 17.01.21 16:00 | Sporting Gijon | Real Betis Sevilla | 0:2 |
| 17.01.21 16:00 | CD Artistico Navalcarnero | SD Eibar | 3:1 |
| 17.01.21 18:00 | AD Alcorcon | FC Valencia | 0:2 |
| 17.01.21 18:00 | CD Teneryfa | FC Villarreal | 0:1 |
| 20.01.21 19:00 | Cordoba CF | Real Sociedad | 0:2 |
| 20.01.21 21:00 | CD Alcoyano | Real Madrid | 2:1p.d. |
| 21.01.21 19:00 | UD Ibiza Eivissa | Athletic Bilbao | 1:2 |
| 21.01.21 21:00 | UE Cornella | FC Barcelona | 0:2p.d. |