| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 30.11.21 16:00 | CD Cayon | SD Huesca | 0:2 |
| 30.11.21 16:00 | CD Marchamalo | Real Valladolid | 0:1 |
| 30.11.21 18:30 | Naxara | Andorra CF | 0:1 |
| 30.11.21 19:00 | Victoria CF | FC Villarreal | 0:8 |
| 30.11.21 19:00 | Unami CP | Deportivo Alaves | 0:3 |
| 30.11.21 19:00 | Santos Laguna | FC Granada | 0:7 |
| 30.11.21 20:00 | UC Ceares | Sporting Gijon | 0:1 |
| 30.11.21 20:00 | Racing Rioja | FC Cartagena | 0:2 |
| 30.11.21 20:00 | CD Teruel | AD Alcorcon | 0:1 |
| 30.11.21 20:30 | Atletico Sanluqueno CF | CD Sabadell | 2:0 |
| 30.11.21 21:00 | CD Badajoz | CD Alcoyano | 0:3 |
| 30.11.21 21:00 | CD Ebro | Celta Vigo | 0:5 |
| 30.11.21 21:00 | Albacete Balompie | Racing de Ferrol | 2:1p.d. |
| 30.11.21 21:00 | CFJ Mollerussa | FC Getafe | 1:5 |
| 30.11.21 21:00 | UD Montijo | Burgos CF | 0:1 |
| 30.11.21 21:00 | CDA Aguilas FC | UD Almeria | 4:6p.k. |
| 01.12.21 16:30 | CD Mensajero | Real Saragossa | 0:1 |
| 01.12.21 18:30 | Bergantinos CF | CD Tudelano | 2:0 |
| 01.12.21 19:00 | SD Solares | Espanyol Barcelona | 2:3 |
| 01.12.21 19:00 | CF Algeciras | Unionistas de Salamanca | 1:2 |
| 01.12.21 19:00 | Cordoba CF | FC Sevilla | 0:1p.d. |
| 01.12.21 19:00 | Gimnastica Segoviana | RCD Mallorca | 0:2p.d. |
| 01.12.21 19:00 | CD Brea | UD Ibiza Eivissa | 0:2 |
| 01.12.21 20:00 | Alzira | CF Fuenlabrada | 0:1 |
| 01.12.21 20:00 | Atletico Mancha Real | Sadcf Internacional De Madrid Dsl | 2:1 |
| 01.12.21 20:00 | CE Andratx | Real Oviedo | 2:1 |
| 01.12.21 20:00 | AD San Juan | San Sebastian de los Reyes | 1:2 |
| 01.12.21 20:00 | UCAM Murcia | Deportivo La Coruna | 3:4p.d. |
| 01.12.21 20:15 | CF Talavera de la Reina | UE Cornella | 2:0 |
| 01.12.21 20:30 | UD Extremadura | Zamora CF | 1:4 |
| 01.12.21 20:30 | Linares Deportivo | Gimnastica Segoviana | 6:5p.k. |
| 01.12.21 20:30 | CD San Fernando | Cultural y Deportiva Leonesa | 2:3 |
| 01.12.21 20:30 | CE Europa | SD Amorebieta | 0:1 |
| 01.12.21 20:30 | CP Cacereno | SD Ponferradina | 1:2 |
| 01.12.21 20:30 | CD Arenteiro | SD Logrones | 2:1 |
| 01.12.21 20:30 | CD Calahorra | Atletico Baleares | 5:6p.k. |
| 01.12.21 21:00 | Hercules Alicante | Real Betis Sevilla | 0:4 |
| 01.12.21 21:00 | Panaderia Pulido | Real Sociedad | 0:4 |
| 01.12.21 21:00 | CD San Roque de Lepe | CD Mirandes | 0:3 |
| 02.12.21 16:00 | Velez CF | UD Las Palmas | 2:3 |
| 02.12.21 19:00 | Huracan Melilla | UD Levante | 0:8 |
| 02.12.21 19:00 | CD Guijuelo | Rayo Vallecano | 4:5p.k. |
| 02.12.21 19:00 | SD Gernika Club | SD Eibar | 1:2 |
| 02.12.21 19:00 | CF San Agustin | CA Osasuna | 0:4 |
| 02.12.21 19:30 | FC Pena Sport | FC Malaga | 0:3 |
| 02.12.21 19:30 | CD Utrillas | FC Valencia | 0:3 |
| 02.12.21 20:00 | CF Cristo Atletico | Real Union Club | 2:0 |
| 02.12.21 20:00 | CS Puertollano | FC Girona | 1:5 |
| 02.12.21 20:00 | UD Llanera | UD Logrones | 2:1 |
| 02.12.21 20:00 | CA Pulpileno | CD Castellon | 0:1 |
| 02.12.21 20:00 | SD Leioa | FC Elche | 0:2 |
| 02.12.21 20:15 | AD Union Adarve | CD Lugo | 5:6p.k. |
| 02.12.21 20:30 | Eldense | CF Rayo Majadahonda | 0:1 |
| 02.12.21 20:45 | Deportivo Xerez | CD Leganes | 1:2 |
| 02.12.21 21:00 | CD Villa de Fortuna | FC Cadiz | 0:7 |
| 02.12.21 21:00 | CD Ibiza Islas Pitiusas | CD Teneryfa | 1:2p.d. |