| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 15.01.22 16:00 | RCD Mallorca | Espanyol Barcelona | 2:1 |
| 15.01.22 18:30 | FC Girona | Rayo Vallecano | 1:2 |
| 15.01.22 18:30 | Sporting Gijon | FC Cadiz | 2:4p.k. |
| 16.01.22 12:00 | Atletico Baleares | FC Valencia | 0:1 |
| 16.01.22 16:00 | Real Betis Sevilla | FC Sevilla | 2:1 |
| 19.01.22 21:00 | Real Sociedad | Atletico Madrid | 2:0 |
| 20.01.22 19:00 | FC Elche | Real Madrid | 1:2p.d. |
| 20.01.22 21:30 | Athletic Bilbao | FC Barcelona | 3:2p.d. |