| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 08.01.21 20:45 | Aston Villa | Liverpool FC | 1:4 |
| 08.01.21 20:45 | Wolverhampton Wanderers | Crystal Palace | 1:0 |
| 09.01.21 13:00 | Boreham Wood | FC Millwall | 0:2 |
| 09.01.21 13:00 | Nottingham Forest | Cardiff City | 1:0 |
| 09.01.21 13:00 | FC Everton | Rotherham United | 2:1p.d. |
| 09.01.21 13:00 | Luton Town | FC Reading | 1:0 |
| 09.01.21 13:00 | Norwich City | Coventry City | 2:0 |
| 09.01.21 13:15 | Chorley FC | Derby County | 2:0 |
| 09.01.21 16:00 | Blackburn Rovers | Doncaster Rovers | 0:1 |
| 09.01.21 16:00 | FC Blackpool | West Bromwich Albion | 5:4p.k. |
| 09.01.21 16:00 | Exeter City | Sheffield Wednesday | 0:2 |
| 09.01.21 16:00 | FC Burnley | Milton Keynes Dons FC | 5:4p.k. |
| 09.01.21 16:00 | Queens Park Rangers | FC Fulham | 0:2p.d. |
| 09.01.21 16:00 | FC Stoke City | Leicester City | 0:4 |
| 09.01.21 16:00 | Wycombe Wanderers | Preston North End | 4:1 |
| 09.01.21 16:00 | Stevenage FC | Swansea City | 0:2 |
| 09.01.21 16:00 | Bristol Rovers | Sheffield United | 2:3 |
| 09.01.21 16:00 | Oldham Athletic | AFC Bournemouth | 1:4 |
| 09.01.21 18:30 | FC Arsenal | Newcastle United | 2:0p.d. |
| 09.01.21 19:00 | Brentford FC | FC Middlesbrough | 2:1 |
| 09.01.21 19:00 | Huddersfield Town | Plymouth Argyle | 2:3 |
| 09.01.21 21:00 | Manchester United | FC Watford | 1:0 |
| 10.01.21 14:30 | Bristol City | FC Portsmouth | 2:1 |
| 10.01.21 14:30 | Crawley Town | Leeds United | 3:0 |
| 10.01.21 14:30 | Manchester City | Birmingham City | 3:0 |
| 10.01.21 14:30 | FC Barnsley | Tranmere Rovers | 2:0 |
| 10.01.21 14:30 | Cheltenham Town | Mansfield Town | 2:1p.d. |
| 10.01.21 14:30 | FC Chelsea | FC Morecambe | 4:0 |
| 10.01.21 18:00 | Marine AFC | Tottenham Hotspur | 0:5 |
| 10.01.21 20:45 | Newport County | Brighton and Hove Albion | 4:5p.k. |
| 11.01.21 21:00 | Stockport County | West Ham United | 0:1 |
| 19.01.21 21:00 | FC Southampton | Shrewsbury Town | 2:0 |