| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 05.11.21 20:55 | AFC Sudbury | Colchester United | 0:4 |
| 06.11.21 14:00 | Scunthorpe United | Doncaster Rovers | 0:1 |
| 06.11.21 15:00 | FC Gillingham | Cheltenham Town | 1:1 |
| 06.11.21 16:00 | FC Gateshead | Altrincham FC | 2:2 |
| 06.11.21 16:00 | York City | Buxton FC | 0:1 |
| 06.11.21 16:00 | Wigan Athletic | Solihull Moors FC | 0:0 |
| 06.11.21 16:00 | Rotherham United | Bromley FC | 3:0 |
| 06.11.21 16:00 | FC Morecambe | Newport County | 1:0 |
| 06.11.21 16:00 | Yate Town FC | Yeovil Town | 0:5 |
| 06.11.21 16:00 | FC Chesterfield | Southend United | 3:1 |
| 06.11.21 16:00 | Crawley Town | Tranmere Rovers | 0:1 |
| 06.11.21 16:00 | Carlisle United | Horsham FC | 2:0 |
| 06.11.21 16:00 | Charlton Athletic | Havant and Waterlooville | 4:0 |
| 06.11.21 16:00 | Hayes and Yeading United F.C. | Sutton United | 0:1 |
| 06.11.21 16:00 | Kings Lynn FC | FC Walsall | 0:1 |
| 06.11.21 16:00 | Leyton Orient | Ebbsfleet United | 1:0 |
| 06.11.21 16:00 | Halifax Town | Maidenhead Utd | 7:4 |
| 06.11.21 16:00 | Fleetwood Town | Burton Albion | 1:2 |
| 06.11.21 16:00 | Milton Keynes Dons FC | Stevenage FC | 2:2 |
| 06.11.21 16:00 | AFC Wimbledon | Guiseley FC | 1:0 |
| 06.11.21 16:00 | Ipswich Town | Oldham Athletic | 1:1 |
| 06.11.21 16:00 | FC Port Vale | Accrington Stanley | 5:1 |
| 06.11.21 16:00 | FC Portsmouth | Harrow Borough | 1:0 |
| 06.11.21 16:00 | Kidderminster Harriers | Grimsby Town | 1:0 |
| 06.11.21 16:00 | Crewe Alexandra | Swindon Town | 0:3 |
| 06.11.21 16:00 | Northampton Town | Cambridge United | 2:2 |
| 06.11.21 16:00 | Lincoln City | Bowers and Pitsea FC | 1:0 |
| 06.11.21 16:00 | AFC Sunderland | Mansfield Town | 0:1 |
| 06.11.21 16:00 | Harrogate Town FC | AFC Wrexham | 2:1 |
| 06.11.21 16:00 | Boreham Wood | Eastleigh FC | 2:0 |
| 06.11.21 16:00 | Hartlepool United | Wycombe Wanderers | 2:2 |
| 06.11.21 16:00 | Bradford City | Exeter City | 1:1 |
| 06.11.21 18:15 | Banbury United | Barrow FC | 0:4 |
| 07.11.21 13:15 | Sheffield Wednesday | Plymouth Argyle | 0:0 |
| 07.11.21 14:00 | Oxford United | Bristol Rovers | 2:2 |
| 07.11.21 16:00 | Stratford Town | Shrewsbury Town | 1:5 |
| 07.11.21 16:00 | Bolton Wanderers | Stockport County | 2:2 |
| 07.11.21 16:00 | FC Rochdale | Notts County | 1:1 |
| 07.11.21 18:15 | St Albans City | Forest Green Rovers | 3:2 |
| 08.11.21 20:45 | Dagenham and Redbridge | Salford City | 0:1 |
| 16.11.21 20:00 | Bristol Rovers | Oxford United | 4:3p.d. |
| 16.11.21 20:45 | Stevenage FC | Milton Keynes Dons FC | 2:1p.d. |
| 16.11.21 20:45 | Oldham Athletic | Ipswich Town | 1:2 |
| 16.11.21 20:45 | Solihull Moors FC | Wigan Athletic | 1:2p.d. |
| 16.11.21 20:45 | Cambridge United | Northampton Town | 3:1 |
| 16.11.21 20:45 | Altrincham FC | FC Gateshead | 2:3 |
| 16.11.21 20:45 | Plymouth Argyle | Sheffield Wednesday | 3:0 |
| 16.11.21 20:45 | Notts County | FC Rochdale | 1:2 |
| 16.11.21 20:45 | Cheltenham Town | FC Gillingham | 1:0 |
| 16.11.21 20:45 | Wycombe Wanderers | Hartlepool United | 0:1 |
| 17.11.21 20:45 | Stockport County | Bolton Wanderers | 5:3p.d. |
| 30.11.21 20:45 | Exeter City | Bradford City | 2:1 |