| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 03.12.21 20:45 | Rotherham United | Stockport County | 1:0 |
| 03.12.21 20:45 | FC Gateshead | Charlton Athletic | 0:2 |
| 04.12.21 13:45 | Buxton FC | FC Morecambe | 0:1 |
| 04.12.21 16:00 | FC Portsmouth | Harrogate Town FC | 1:2 |
| 04.12.21 16:00 | Bristol Rovers | Sutton United | 2:1 |
| 04.12.21 16:00 | FC Walsall | Swindon Town | 1:2 |
| 04.12.21 16:00 | Ipswich Town | Barrow FC | 0:0 |
| 04.12.21 16:00 | Lincoln City | Hartlepool United | 0:1 |
| 04.12.21 16:00 | Cambridge United | Exeter City | 2:1 |
| 04.12.21 16:00 | Burton Albion | FC Port Vale | 1:2 |
| 04.12.21 16:00 | Carlisle United | Shrewsbury Town | 1:2 |
| 04.12.21 16:00 | Doncaster Rovers | Mansfield Town | 2:3 |
| 04.12.21 16:00 | Leyton Orient | Tranmere Rovers | 4:0 |
| 04.12.21 16:00 | AFC Wimbledon | Cheltenham Town | 4:3 |
| 04.12.21 18:30 | Yeovil Town | Stevenage FC | 1:0 |
| 05.12.21 13:15 | FC Rochdale | Plymouth Argyle | 1:2 |
| 05.12.21 13:30 | Colchester United | Wigan Athletic | 1:2 |
| 05.12.21 17:00 | Kidderminster Harriers | Halifax Town | 2:0 |
| 05.12.21 18:15 | Salford City | FC Chesterfield | 0:2 |
| 06.12.21 20:45 | Boreham Wood | St Albans City | 4:0 |
| 15.12.21 20:45 | Barrow FC | Ipswich Town | 2:0 |