| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 07.01.22 21:00 | Swindon Town | Manchester City | 1:4 |
| 08.01.22 13:15 | Mansfield Town | FC Middlesbrough | 2:3 |
| 08.01.22 13:30 | FC Burnley | Huddersfield Town | 1:2 |
| 08.01.22 13:30 | Bristol City | FC Fulham | 0:1p.d. |
| 08.01.22 13:30 | Hartlepool United | FC Blackpool | 2:1 |
| 08.01.22 13:30 | Coventry City | Derby County | 1:0 |
| 08.01.22 13:45 | FC Millwall | Crystal Palace | 1:2 |
| 08.01.22 16:00 | Boreham Wood | AFC Wimbledon | 2:0 |
| 08.01.22 16:00 | Peterborough United | Bristol Rovers | 2:1 |
| 08.01.22 16:00 | Leicester City | FC Watford | 4:1 |
| 08.01.22 16:00 | FC Port Vale | Brentford FC | 1:4 |
| 08.01.22 16:00 | Queens Park Rangers | Rotherham United | 9:8p.k. |
| 08.01.22 16:00 | FC Barnsley | Barrow FC | 5:4p.d. |
| 08.01.22 16:00 | Kidderminster Harriers | FC Reading | 2:1 |
| 08.01.22 16:00 | West Bromwich Albion | Brighton and Hove Albion | 1:2p.d. |
| 08.01.22 16:00 | Newcastle United | Cambridge United | 0:1 |
| 08.01.22 16:00 | Wigan Athletic | Blackburn Rovers | 3:2 |
| 08.01.22 18:30 | Swansea City | FC Southampton | 2:3p.d. |
| 08.01.22 18:30 | Hull City A.F.C. | FC Everton | 2:3p.d. |
| 08.01.22 18:30 | Birmingham City | Plymouth Argyle | 0:1p.d. |
| 08.01.22 18:30 | FC Chelsea | FC Chesterfield | 5:1 |
| 08.01.22 18:45 | Yeovil Town | AFC Bournemouth | 1:3 |
| 09.01.22 13:30 | Luton Town | Harrogate Town FC | 4:0 |
| 09.01.22 15:00 | Tottenham Hotspur | FC Morecambe | 3:1 |
| 09.01.22 15:00 | FC Stoke City | Leyton Orient | 2:0 |
| 09.01.22 15:00 | Liverpool FC | Shrewsbury Town | 4:1 |
| 09.01.22 15:00 | Cardiff City | Preston North End | 2:1p.d. |
| 09.01.22 15:00 | Charlton Athletic | Norwich City | 0:1 |
| 09.01.22 15:00 | Wolverhampton Wanderers | Sheffield United | 3:0 |
| 09.01.22 15:00 | West Ham United | Leeds United | 2:0 |
| 09.01.22 18:10 | Nottingham Forest | FC Arsenal | 1:0 |
| 10.01.22 20:55 | Manchester United | Aston Villa | 1:0 |