| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 04.02.22 21:00 | Manchester United | FC Middlesbrough | 8:9p.k. |
| 05.02.22 13:30 | Kidderminster Harriers | West Ham United | 1:2p.d. |
| 05.02.22 13:30 | FC Chelsea | Plymouth Argyle | 2:1p.d. |
| 05.02.22 16:00 | Crystal Palace | Hartlepool United | 2:0 |
| 05.02.22 16:00 | FC Everton | Brentford FC | 4:1 |
| 05.02.22 16:00 | FC Stoke City | Wigan Athletic | 2:0 |
| 05.02.22 16:00 | Peterborough United | Queens Park Rangers | 2:0 |
| 05.02.22 16:00 | Manchester City | FC Fulham | 4:1 |
| 05.02.22 16:00 | FC Southampton | Coventry City | 2:1p.d. |
| 05.02.22 16:00 | Huddersfield Town | FC Barnsley | 1:0 |
| 05.02.22 16:00 | Wolverhampton Wanderers | Norwich City | 0:1 |
| 05.02.22 18:30 | Cambridge United | Luton Town | 0:3 |
| 05.02.22 21:00 | Tottenham Hotspur | Brighton and Hove Albion | 3:1 |
| 06.02.22 13:00 | Liverpool FC | Cardiff City | 3:1 |
| 06.02.22 17:00 | Nottingham Forest | Leicester City | 4:1 |
| 06.02.22 19:30 | AFC Bournemouth | Boreham Wood | 0:1 |