| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 05.05.18 02:00 | Toronto FC | Philadelphia Union | 3:0 |
| 05.05.18 19:00 | CF Montreal | New England Revolution | 4:2 |
| 05.05.18 19:55 | New York Red Bulls | New York City FC | 4:0 |
| 05.05.18 20:00 | Minnesota United FC | Vancouver Whitecaps | 1:0 |
| 05.05.18 21:55 | Los Angeles FC | FC Dallas | 1:1 |
| 05.05.18 22:00 | Seattle Sounders | Columbus Crew | 0:0 |
| 06.05.18 02:30 | Chicago Fire | Atlanta United FC | 1:2 |
| 06.05.18 02:30 | Houston Dynamo | Los Angeles Galaxy | 3:2 |
| 06.05.18 02:30 | Sporting Kansas City | Colorado Rapids | 1:0 |
| 06.05.18 04:30 | San Jose Earthquakes | Portland Timbers | 0:1 |
| 06.05.18 23:00 | Orlando City | Real Salt Lake | 3:1 |