| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 13.09.18 01:30 | D.C. United | Minnesota United FC | 2:1 |
| 15.09.18 21:30 | Colorado Rapids | Atlanta United FC | 0:3 |
| 16.09.18 01:30 | Philadelphia Union | CF Montreal | 1:4 |
| 16.09.18 01:30 | Toronto FC | Los Angeles Galaxy | 5:3 |
| 16.09.18 02:00 | FC Dallas | Columbus Crew | 0:0 |
| 16.09.18 02:30 | Houston Dynamo | Portland Timbers | 4:1 |
| 16.09.18 03:30 | Real Salt Lake | Minnesota United FC | 1:1 |
| 16.09.18 04:00 | Vancouver Whitecaps | Seattle Sounders | 1:2 |
| 16.09.18 04:30 | Los Angeles FC | New England Revolution | 1:1 |
| 16.09.18 04:30 | San Jose Earthquakes | Sporting Kansas City | 1:5 |
| 16.09.18 19:00 | D.C. United | New York Red Bulls | 3:3 |
| 16.09.18 23:00 | Chicago Fire | Orlando City | 4:0 |