| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 27.09.18 01:00 | New York City FC | Chicago Fire | 2:0 |
| 29.09.18 21:30 | Chicago Fire | Los Angeles FC | 3:1 |
| 29.09.18 22:00 | Seattle Sounders | Colorado Rapids | 4:0 |
| 30.09.18 01:00 | D.C. United | CF Montreal | 5:0 |
| 30.09.18 01:30 | Columbus Crew | Philadelphia Union | 0:0 |
| 30.09.18 01:30 | Toronto FC | New England Revolution | 4:1 |
| 30.09.18 02:00 | Minnesota United FC | New York City FC | 2:1 |
| 30.09.18 02:30 | Houston Dynamo | San Jose Earthquakes | 3:2 |
| 30.09.18 04:00 | Los Angeles Galaxy | Vancouver Whitecaps | 3:0 |
| 30.09.18 04:30 | Portland Timbers | FC Dallas | 0:0 |
| 30.09.18 19:00 | New York Red Bulls | Atlanta United FC | 2:0 |
| 30.09.18 23:00 | Sporting Kansas City | Real Salt Lake | 1:1 |