| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 21.04.18 03:00 | Sporting Kansas City | Vancouver Whitecaps | 6:0 |
| 21.04.18 19:00 | CF Montreal | Los Angeles FC | 3:5 |
| 21.04.18 21:00 | Houston Dynamo | Toronto FC | 5:1 |
| 21.04.18 21:30 | New York Red Bulls | Chicago Fire | 1:2 |
| 22.04.18 01:30 | Orlando City | San Jose Earthquakes | 3:2 |
| 22.04.18 01:30 | Columbus Crew | New England Revolution | 2:2 |
| 22.04.18 02:00 | FC Dallas | Philadelphia Union | 2:0 |
| 22.04.18 03:00 | Real Salt Lake | Colorado Rapids | 3:0 |
| 22.04.18 04:30 | Los Angeles Galaxy | Atlanta United FC | 0:2 |
| 22.04.18 22:00 | Seattle Sounders | Minnesota United FC | 3:1 |
| 23.04.18 00:00 | Portland Timbers | New York City FC | 3:0 |