| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 28.04.18 04:30 | Vancouver Whitecaps | Real Salt Lake | 2:0 |
| 28.04.18 19:00 | Atlanta United FC | CF Montreal | 4:1 |
| 28.04.18 21:00 | Toronto FC | Chicago Fire | 2:2 |
| 28.04.18 21:30 | Philadelphia Union | D.C. United | 3:2 |
| 29.04.18 01:30 | Columbus Crew | San Jose Earthquakes | 2:1 |
| 29.04.18 01:30 | New England Revolution | Sporting Kansas City | 1:0 |
| 29.04.18 02:00 | Minnesota United FC | Houston Dynamo | 2:1 |
| 29.04.18 04:30 | Los Angeles Galaxy | New York Red Bulls | 2:3 |
| 29.04.18 22:00 | Colorado Rapids | Orlando City | 1:2 |
| 30.04.18 00:30 | New York City FC | FC Dallas | 3:1 |
| 30.04.18 03:00 | Los Angeles FC | Seattle Sounders | 1:0 |