| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 03.10.20 22:30 | Orlando City | New York Red Bulls | 3:1 |
| 04.10.20 01:00 | D.C. United | Atlanta United FC | 0:4 |
| 04.10.20 01:30 | Toronto FC | Philadelphia Union | 2:1 |
| 04.10.20 01:30 | New England Revolution | Nashville SC | 0:0 |
| 04.10.20 01:30 | CF Montreal | Chicago Fire | 2:2 |
| 04.10.20 02:00 | Minnesota United FC | Cincinnati FC | 2:0 |
| 04.10.20 02:00 | Inter Miami CF | New York City FC | 2:3 |
| 04.10.20 02:00 | Houston Dynamo | Sporting Kansas City | 1:2 |
| 04.10.20 02:30 | FC Dallas | Columbus Crew | 2:2 |
| 04.10.20 04:00 | Seattle Sounders | Vancouver Whitecaps | 3:1 |
| 04.10.20 04:30 | San Jose Earthquakes | Los Angeles Galaxy | 2:1 |
| 05.10.20 03:30 | Real Salt Lake | Los Angeles FC | 1:3 |
| 05.11.20 04:00 | Portland Timbers | Colorado Rapids | 0:1 |