| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 17.10.20 21:30 | Chicago Fire | Sporting Kansas City | 2:2 |
| 18.10.20 01:00 | CF Montreal | Inter Miami CF | 2:1 |
| 19.10.20 00:00 | Columbus Crew | New York City FC | 3:1 |
| 19.10.20 01:00 | New York Red Bulls | Orlando City | 1:1 |
| 19.10.20 01:30 | Toronto FC | Atlanta United FC | 1:0 |
| 19.10.20 01:30 | Cincinnati FC | D.C. United | 1:2 |
| 19.10.20 02:00 | Minnesota United FC | Houston Dynamo | 2:2 |
| 19.10.20 04:00 | Portland Timbers | Los Angeles FC | 1:1 |
| 19.10.20 04:30 | San Jose Earthquakes | Seattle Sounders | 0:0 |
| 19.10.20 04:30 | Los Angeles Galaxy | Vancouver Whitecaps | 1:0 |
| 20.10.20 01:30 | New England Revolution | Philadelphia Union | 1:2 |
| 21.10.20 02:30 | Nashville SC | FC Dallas | 3:0 |