| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 28.10.20 00:00 | CF Montreal | Nashville SC | 0:1 |
| 28.10.20 03:00 | Vancouver Whitecaps | Seattle Sounders | 0:2 |
| 29.10.20 00:00 | New York Red Bulls | New England Revolution | 1:0 |
| 29.10.20 00:30 | Toronto FC | New York City FC | 0:1 |
| 29.10.20 00:30 | Philadelphia Union | Chicago Fire | 2:1 |
| 29.10.20 00:30 | Orlando City | Atlanta United FC | 4:1 |
| 29.10.20 00:30 | Cincinnati FC | Sporting Kansas City | 0:1 |
| 29.10.20 01:00 | Minnesota United FC | Colorado Rapids | 2:1 |
| 29.10.20 01:00 | D.C. United | Columbus Crew | 1:0 |
| 29.10.20 01:30 | FC Dallas | Inter Miami CF | 2:1 |
| 29.10.20 03:00 | Portland Timbers | Los Angeles Galaxy | 5:2 |
| 29.10.20 03:30 | San Jose Earthquakes | Real Salt Lake | 2:0 |
| 29.10.20 03:30 | Los Angeles FC | Houston Dynamo | 2:1 |