| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 05.11.20 02:30 | Nashville SC | FC Dallas | 0:1 |
| 05.11.20 05:00 | Los Angeles Galaxy | Seattle Sounders | 1:1 |
| 08.11.20 21:30 | Philadelphia Union | New England Revolution | 2:0 |
| 08.11.20 21:30 | Orlando City | Nashville SC | 2:3 |
| 08.11.20 21:30 | New York Red Bulls | Toronto FC | 2:1 |
| 08.11.20 21:30 | Inter Miami CF | Cincinnati FC | 2:1 |
| 08.11.20 21:30 | D.C. United | CF Montreal | 2:3 |
| 08.11.20 21:30 | Columbus Crew | Atlanta United FC | 2:1 |
| 08.11.20 21:30 | Chicago Fire | New York City FC | 3:4 |
| 09.11.20 00:30 | Vancouver Whitecaps | Los Angeles Galaxy | 3:0 |
| 09.11.20 00:30 | Seattle Sounders | San Jose Earthquakes | 4:1 |
| 09.11.20 00:30 | Real Salt Lake | Sporting Kansas City | 0:2 |
| 09.11.20 00:30 | Minnesota United FC | FC Dallas | 3:0 |
| 09.11.20 00:30 | Los Angeles FC | Portland Timbers | 1:1 |
| 09.11.20 00:30 | Houston Dynamo | Colorado Rapids | 1:2 |