| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 10.09.20 02:00 | Minnesota United FC | FC Dallas | 3:2 |
| 10.09.20 02:00 | CF Montreal | Toronto FC | 1:2 |
| 10.09.20 02:00 | Inter Miami CF | Atlanta United FC | 2:1 |
| 10.09.20 03:00 | Colorado Rapids | Houston Dynamo | 1:1 |
| 10.09.20 03:30 | Real Salt Lake | Los Angeles FC | 3:0 |
| 11.09.20 04:00 | Seattle Sounders | San Jose Earthquakes | 7:1 |
| 12.09.20 21:30 | Chicago Fire | Columbus Crew | 2:2 |
| 13.09.20 01:00 | D.C. United | New York Red Bulls | 0:2 |
| 13.09.20 01:00 | New York City FC | Cincinnati FC | 2:1 |
| 13.09.20 01:30 | Philadelphia Union | New England Revolution | 2:1 |
| 13.09.20 01:30 | Orlando City | Inter Miami CF | 2:1 |
| 13.09.20 02:30 | Nashville SC | Atlanta United FC | 4:2 |
| 13.09.20 02:30 | FC Dallas | Houston Dynamo | 2:1 |
| 13.09.20 03:30 | Real Salt Lake | Colorado Rapids | 0:5 |
| 14.09.20 02:30 | Sporting Kansas City | Minnesota United FC | 1:0 |
| 14.09.20 03:30 | Vancouver Whitecaps | CF Montreal | 2:4 |
| 14.09.20 05:00 | Los Angeles FC | Portland Timbers | 4:2 |
| 14.09.20 05:00 | San Jose Earthquakes | Los Angeles Galaxy | 0:0 |
| 17.09.20 02:30 | FC Dallas | Colorado Rapids | 4:1 |
| 17.09.20 03:30 | Vancouver Whitecaps | CF Montreal | 3:1 |
| 17.09.20 03:30 | San Jose Earthquakes | Portland Timbers | 1:1 |