| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 19.09.20 04:00 | Seattle Sounders | Los Angeles FC | 3:0 |
| 19.09.20 21:30 | Sporting Kansas City | FC Dallas | 2:3 |
| 19.09.20 22:30 | New England Revolution | New York City FC | 0:0 |
| 20.09.20 01:00 | New York Red Bulls | Cincinnati FC | 0:1 |
| 20.09.20 01:00 | Atlanta United FC | Inter Miami CF | 1:2 |
| 20.09.20 01:30 | Columbus Crew | Nashville SC | 2:0 |
| 20.09.20 01:30 | D.C. United | Toronto FC | 2:2 |
| 20.09.20 01:30 | Orlando City | Chicago Fire | 4:1 |
| 20.09.20 02:00 | Houston Dynamo | Minnesota United FC | 2:2 |
| 20.09.20 03:30 | Real Salt Lake | Vancouver Whitecaps | 1:2 |
| 20.09.20 04:30 | San Jose Earthquakes | Portland Timbers | 1:6 |
| 20.09.20 04:30 | Los Angeles Galaxy | Colorado Rapids | 0:2 |
| 21.09.20 01:00 | CF Montreal | Philadelphia Union | 1:4 |