| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 17.04.21 02:00 | Houston Dynamo | San Jose Earthquakes | 2:1 |
| 17.04.21 03:30 | Seattle Sounders | Minnesota United FC | 4:0 |
| 17.04.21 20:00 | CF Montreal | Toronto FC | 4:2 |
| 17.04.21 21:00 | Orlando City | Atlanta United FC | 0:0 |
| 18.04.21 00:00 | Los Angeles FC | Austin FC | 2:0 |
| 18.04.21 02:00 | D.C. United | New York City FC | 2:1 |
| 18.04.21 02:00 | FC Dallas | Colorado Rapids | 0:0 |
| 18.04.21 02:00 | New York Red Bulls | Sporting Kansas City | 1:2 |
| 18.04.21 02:30 | Chicago Fire | New England Revolution | 2:2 |
| 18.04.21 02:30 | Nashville SC | Cincinnati FC | 2:2 |
| 18.04.21 21:20 | Inter Miami CF | Los Angeles Galaxy | 2:3 |
| 18.04.21 23:30 | Columbus Crew | Philadelphia Union | 0:0 |
| 19.04.21 04:00 | Vancouver Whitecaps | Portland Timbers | 1:0 |