| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 26.06.21 02:00 | Inter Miami CF | Orlando City | 1:2 |
| 26.06.21 23:30 | Sporting Kansas City | Los Angeles FC | 2:1 |
| 27.06.21 01:00 | Toronto FC | Cincinnati FC | 0:2 |
| 27.06.21 02:00 | Real Salt Lake | Houston Dynamo | 1:1 |
| 27.06.21 02:00 | Chicago Fire | Philadelphia Union | 3:3 |
| 27.06.21 02:30 | Nashville SC | CF Montreal | 1:1 |
| 27.06.21 03:00 | Seattle Sounders | Vancouver Whitecaps | 2:2 |
| 27.06.21 04:00 | San Jose Earthquakes | Los Angeles Galaxy | 1:3 |
| 27.06.21 05:30 | Portland Timbers | Minnesota United FC | 0:1 |
| 27.06.21 21:30 | Atlanta United FC | New York Red Bulls | 0:0 |
| 28.06.21 00:00 | New York City FC | D.C. United | 2:1 |
| 28.06.21 02:00 | Austin FC | Columbus Crew | 0:0 |
| 28.06.21 03:00 | FC Dallas | New England Revolution | 2:1 |