| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 02.07.21 03:30 | Austin FC | Portland Timbers | 4:1 |
| 03.07.21 23:00 | Columbus Crew | New England Revolution | 2:2 |
| 03.07.21 23:30 | D.C. United | Toronto FC | 7:1 |
| 04.07.21 01:30 | CF Montreal | Inter Miami CF | 1:0 |
| 04.07.21 01:30 | Orlando City | New York Red Bulls | 1:2 |
| 04.07.21 02:00 | Nashville SC | Philadelphia Union | 1:0 |
| 04.07.21 02:00 | Minnesota United FC | San Jose Earthquakes | 2:2 |
| 04.07.21 02:00 | Chicago Fire | Atlanta United FC | 3:0 |
| 04.07.21 02:30 | Houston Dynamo | Cincinnati FC | 1:1 |
| 04.07.21 04:00 | Real Salt Lake | Los Angeles FC | 0:1 |
| 05.07.21 02:30 | FC Dallas | Vancouver Whitecaps | 2:2 |
| 05.07.21 03:00 | Colorado Rapids | Seattle Sounders | 1:1 |
| 05.07.21 04:30 | Los Angeles Galaxy | Sporting Kansas City | 0:2 |