| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 21.07.21 04:00 | Vancouver Whitecaps | Houston Dynamo | 0:0 |
| 22.07.21 01:30 | New York City FC | CF Montreal | 1:0 |
| 22.07.21 01:30 | Toronto FC | New York Red Bulls | 1:1 |
| 22.07.21 01:30 | Inter Miami CF | New England Revolution | 0:5 |
| 22.07.21 01:30 | Columbus Crew | Nashville SC | 0:0 |
| 22.07.21 02:00 | Cincinnati FC | Atlanta United FC | 1:1 |
| 22.07.21 02:00 | Chicago Fire | D.C. United | 2:2 |
| 22.07.21 02:30 | Sporting Kansas City | San Jose Earthquakes | 1:1 |
| 22.07.21 03:00 | Colorado Rapids | FC Dallas | 2:0 |
| 22.07.21 04:00 | Real Salt Lake | Los Angeles Galaxy | 2:2 |
| 22.07.21 04:30 | Portland Timbers | Los Angeles FC | 2:1 |
| 23.07.21 01:30 | Orlando City | Philadelphia Union | 2:1 |
| 23.07.21 03:30 | Austin FC | Seattle Sounders | 0:1 |