| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 24.07.21 21:30 | Atlanta United FC | Columbus Crew | 0:1 |
| 25.07.21 02:00 | Chicago Fire | Toronto FC | 1:2 |
| 25.07.21 02:00 | Minnesota United FC | Portland Timbers | 2:1 |
| 25.07.21 02:30 | Nashville SC | Cincinnati FC | 3:0 |
| 25.07.21 02:30 | FC Dallas | Los Angeles Galaxy | 4:0 |
| 25.07.21 04:00 | San Jose Earthquakes | Houston Dynamo | 1:1 |
| 25.07.21 04:00 | Real Salt Lake | Colorado Rapids | 3:0 |
| 25.07.21 04:30 | Los Angeles FC | Vancouver Whitecaps | 2:2 |
| 26.07.21 00:00 | New England Revolution | CF Montreal | 2:1 |
| 26.07.21 00:00 | New York City FC | Orlando City | 5:0 |
| 26.07.21 01:30 | Inter Miami CF | Philadelphia Union | 1:1 |
| 26.07.21 02:00 | D.C. United | New York Red Bulls | 1:0 |
| 26.07.21 03:00 | Seattle Sounders | Sporting Kansas City | 1:3 |