| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 05.08.21 01:00 | New England Revolution | Nashville SC | 0:0 |
| 05.08.21 01:30 | Philadelphia Union | Toronto FC | 3:0 |
| 05.08.21 01:30 | CF Montreal | Atlanta United FC | 2:2 |
| 05.08.21 01:30 | Columbus Crew | D.C. United | 2:4 |
| 05.08.21 02:00 | New York Red Bulls | Cincinnati FC | 0:0 |
| 05.08.21 02:00 | Chicago Fire | New York City FC | 0:0 |
| 05.08.21 02:00 | Orlando City | Inter Miami CF | 1:1 |
| 05.08.21 03:00 | Austin FC | Houston Dynamo | 3:2 |
| 05.08.21 04:00 | Seattle Sounders | FC Dallas | 1:1 |
| 05.08.21 04:30 | Los Angeles Galaxy | Real Salt Lake | 1:0 |
| 05.08.21 04:30 | Portland Timbers | San Jose Earthquakes | 1:1 |
| 05.08.21 04:30 | Los Angeles FC | Sporting Kansas City | 1:4 |
| 10.10.21 22:00 | Minnesota United FC | Colorado Rapids | 1:3 |