| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 08.08.21 01:30 | Cincinnati FC | Orlando City | 1:1 |
| 08.08.21 01:30 | Columbus Crew | Atlanta United FC | 2:3 |
| 08.08.21 02:00 | Toronto FC | New York City FC | 2:2 |
| 08.08.21 02:00 | Minnesota United FC | Houston Dynamo | 2:0 |
| 08.08.21 02:30 | FC Dallas | Austin FC | 2:0 |
| 08.08.21 03:00 | Colorado Rapids | Sporting Kansas City | 0:0 |
| 08.08.21 04:30 | Portland Timbers | Real Salt Lake | 3:2 |
| 09.08.21 00:00 | Chicago Fire | New York Red Bulls | 2:1 |
| 09.08.21 00:00 | Inter Miami CF | Nashville SC | 2:1 |
| 09.08.21 00:00 | New England Revolution | Philadelphia Union | 2:1 |
| 09.08.21 01:00 | San Jose Earthquakes | Los Angeles FC | 2:1 |
| 09.08.21 02:00 | D.C. United | CF Montreal | 2:1 |
| 09.08.21 02:00 | Los Angeles Galaxy | Vancouver Whitecaps | 1:1 |