| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 14.08.21 04:30 | San Jose Earthquakes | Vancouver Whitecaps | 0:0 |
| 15.08.21 00:00 | Minnesota United FC | Los Angeles Galaxy | 0:1 |
| 15.08.21 02:00 | Toronto FC | New England Revolution | 1:2 |
| 15.08.21 02:00 | CF Montreal | New York Red Bulls | 2:1 |
| 15.08.21 02:00 | New York City FC | Inter Miami CF | 2:0 |
| 15.08.21 02:30 | Houston Dynamo | Colorado Rapids | 1:3 |
| 15.08.21 02:30 | FC Dallas | Sporting Kansas City | 0:2 |
| 15.08.21 04:00 | Real Salt Lake | Austin FC | 1:0 |
| 15.08.21 22:00 | Atlanta United FC | Los Angeles FC | 1:0 |
| 16.08.21 00:00 | Chicago Fire | Columbus Crew | 1:0 |
| 16.08.21 01:00 | Nashville SC | D.C. United | 5:2 |
| 16.08.21 04:00 | Portland Timbers | Seattle Sounders | 2:6 |
| 10.10.21 02:00 | Cincinnati FC | Philadelphia Union | 1:2 |