| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 18.08.21 04:30 | San Jose Earthquakes | Minnesota United FC | 1:1 |
| 18.08.21 04:30 | Los Angeles Galaxy | Colorado Rapids | 1:2 |
| 19.08.21 01:00 | New England Revolution | D.C. United | 3:2 |
| 19.08.21 01:00 | Atlanta United FC | Toronto FC | 1:0 |
| 19.08.21 01:30 | Inter Miami CF | Chicago Fire | 3:2 |
| 19.08.21 01:30 | Philadelphia Union | New York City FC | 1:0 |
| 19.08.21 01:30 | Cincinnati FC | CF Montreal | 0:0 |
| 19.08.21 02:00 | New York Red Bulls | Columbus Crew | 1:0 |
| 19.08.21 02:30 | Sporting Kansas City | Portland Timbers | 1:1 |
| 19.08.21 02:30 | Nashville SC | Orlando City | 1:1 |
| 19.08.21 02:30 | FC Dallas | Seattle Sounders | 0:1 |
| 19.08.21 03:00 | Austin FC | Vancouver Whitecaps | 1:2 |
| 19.08.21 04:00 | Real Salt Lake | Houston Dynamo | 2:1 |