| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 21.08.21 04:30 | Los Angeles Galaxy | San Jose Earthquakes | 1:2 |
| 21.08.21 21:30 | Minnesota United FC | Sporting Kansas City | 0:0 |
| 21.08.21 23:30 | Columbus Crew | Seattle Sounders | 1:2 |
| 22.08.21 02:00 | D.C. United | Atlanta United FC | 1:2 |
| 22.08.21 02:00 | Orlando City | Chicago Fire | 1:0 |
| 22.08.21 02:00 | New England Revolution | Cincinnati FC | 4:1 |
| 22.08.21 02:00 | Inter Miami CF | Toronto FC | 3:1 |
| 22.08.21 02:00 | Philadelphia Union | CF Montreal | 1:1 |
| 22.08.21 02:30 | Houston Dynamo | FC Dallas | 2:2 |
| 22.08.21 03:00 | Austin FC | Portland Timbers | 3:1 |
| 22.08.21 03:00 | Colorado Rapids | Real Salt Lake | 2:1 |
| 22.08.21 04:00 | Vancouver Whitecaps | Los Angeles FC | 2:1 |
| 23.09.21 02:00 | New York Red Bulls | New York City FC | 1:1 |