| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 28.08.21 00:30 | Columbus Crew | Cincinnati FC | 3:2 |
| 28.08.21 01:30 | CF Montreal | Toronto FC | 3:1 |
| 28.08.21 02:30 | Orlando City | Inter Miami CF | 0:0 |
| 28.08.21 21:30 | Atlanta United FC | Nashville SC | 0:2 |
| 29.08.21 00:00 | New York Red Bulls | Chicago Fire | 0:1 |
| 29.08.21 01:00 | Los Angeles FC | Los Angeles Galaxy | 3:3 |
| 29.08.21 01:30 | New York City FC | New England Revolution | 2:0 |
| 29.08.21 02:00 | D.C. United | Philadelphia Union | 3:1 |
| 29.08.21 03:00 | Houston Dynamo | Minnesota United FC | 1:2 |
| 29.08.21 03:00 | Sporting Kansas City | Colorado Rapids | 1:1 |
| 30.08.21 02:00 | Austin FC | FC Dallas | 3:5 |
| 30.08.21 04:00 | Vancouver Whitecaps | Real Salt Lake | 4:1 |
| 30.08.21 04:30 | Seattle Sounders | Portland Timbers | 0:2 |