| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 11.09.21 01:00 | Atlanta United FC | Orlando City | 3:0 |
| 11.09.21 04:00 | Vancouver Whitecaps | Portland Timbers | 0:1 |
| 11.09.21 21:30 | Colorado Rapids | Los Angeles Galaxy | 1:1 |
| 11.09.21 23:00 | Seattle Sounders | Minnesota United FC | 1:0 |
| 12.09.21 01:00 | New York Red Bulls | D.C. United | 1:1 |
| 12.09.21 01:00 | New England Revolution | New York City FC | 2:1 |
| 12.09.21 02:00 | Cincinnati FC | Toronto FC | 2:0 |
| 12.09.21 02:00 | CF Montreal | Nashville SC | 0:1 |
| 12.09.21 02:00 | Inter Miami CF | Columbus Crew | 1:0 |
| 12.09.21 02:30 | Sporting Kansas City | Chicago Fire | 2:0 |
| 12.09.21 02:30 | Houston Dynamo | Austin FC | 3:0 |
| 12.09.21 02:30 | FC Dallas | San Jose Earthquakes | 1:1 |
| 13.09.21 04:30 | Los Angeles FC | Real Salt Lake | 3:2 |