| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 01.05.21 19:00 | New York Red Bulls | Chicago Fire | 2:0 |
| 01.05.21 20:00 | Real Salt Lake | Sporting Kansas City | 3:1 |
| 01.05.21 21:00 | CF Montreal | Columbus Crew | 0:0 |
| 01.05.21 21:30 | Houston Dynamo | Los Angeles FC | 1:1 |
| 02.05.21 01:00 | New England Revolution | Atlanta United FC | 2:1 |
| 02.05.21 01:30 | Orlando City | Cincinnati FC | 3:0 |
| 02.05.21 01:30 | Philadelphia Union | New York City FC | 0:2 |
| 02.05.21 02:00 | Minnesota United FC | Austin FC | 0:1 |
| 02.05.21 02:00 | FC Dallas | Portland Timbers | 4:1 |
| 02.05.21 05:00 | San Jose Earthquakes | D.C. United | 4:1 |
| 02.05.21 19:00 | Nashville SC | Inter Miami CF | 0:0 |
| 03.05.21 03:00 | Seattle Sounders | Los Angeles Galaxy | 3:0 |
| 03.05.21 04:00 | Vancouver Whitecaps | Colorado Rapids | 0:1 |