| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 16.10.21 19:00 | CF Montreal | Philadelphia Union | 2:2 |
| 16.10.21 21:30 | Los Angeles FC | San Jose Earthquakes | 3:1 |
| 17.10.21 00:00 | Columbus Crew | Inter Miami CF | 4:0 |
| 17.10.21 01:00 | New England Revolution | Chicago Fire | 2:2 |
| 17.10.21 01:30 | D.C. United | Nashville SC | 0:0 |
| 17.10.21 01:30 | Cincinnati FC | Orlando City | 0:1 |
| 17.10.21 01:30 | Toronto FC | Atlanta United FC | 0:2 |
| 17.10.21 02:30 | Houston Dynamo | Seattle Sounders | 2:1 |
| 17.10.21 03:00 | Austin FC | Minnesota United FC | 0:1 |
| 17.10.21 03:30 | Real Salt Lake | Colorado Rapids | 3:1 |
| 17.10.21 04:30 | Los Angeles Galaxy | Portland Timbers | 2:1 |
| 17.10.21 19:00 | New York Red Bulls | New York City FC | 1:0 |
| 18.10.21 04:00 | Vancouver Whitecaps | Sporting Kansas City | 2:1 |