| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 21.10.21 01:30 | Orlando City | CF Montreal | 1:1 |
| 21.10.21 01:30 | Inter Miami CF | Toronto FC | 3:0 |
| 21.10.21 01:30 | Atlanta United FC | New York City FC | 1:1 |
| 21.10.21 01:30 | D.C. United | New England Revolution | 2:3 |
| 21.10.21 01:30 | Cincinnati FC | Chicago Fire | 3:4 |
| 21.10.21 02:00 | FC Dallas | Los Angeles FC | 2:3 |
| 21.10.21 02:00 | Minnesota United FC | Philadelphia Union | 3:2 |
| 21.10.21 02:30 | Nashville SC | Columbus Crew | 1:1 |
| 21.10.21 02:30 | Houston Dynamo | Los Angeles Galaxy | 0:3 |
| 21.10.21 03:00 | Colorado Rapids | Seattle Sounders | 1:1 |
| 21.10.21 04:00 | Portland Timbers | Vancouver Whitecaps | 2:3 |
| 21.10.21 04:30 | San Jose Earthquakes | Austin FC | 4:0 |