| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 23.10.21 21:30 | Seattle Sounders | Sporting Kansas City | 1:2 |
| 24.10.21 00:00 | Columbus Crew | New York Red Bulls | 1:2 |
| 24.10.21 01:30 | Toronto FC | CF Montreal | 1:1 |
| 24.10.21 01:30 | Philadelphia Union | Nashville SC | 1:0 |
| 24.10.21 01:30 | New York City FC | D.C. United | 6:0 |
| 24.10.21 02:00 | Inter Miami CF | Cincinnati FC | 5:1 |
| 24.10.21 02:00 | Chicago Fire | Real Salt Lake | 1:0 |
| 24.10.21 02:00 | Minnesota United FC | Los Angeles FC | 1:1 |
| 24.10.21 03:00 | Colorado Rapids | Portland Timbers | 2:0 |
| 24.10.21 04:00 | San Jose Earthquakes | Vancouver Whitecaps | 1:1 |
| 24.10.21 04:00 | Los Angeles Galaxy | FC Dallas | 2:2 |
| 24.10.21 23:00 | Austin FC | Houston Dynamo | 2:1 |
| 25.10.21 01:30 | Orlando City | New England Revolution | 2:2 |