| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 27.10.21 04:30 | Los Angeles FC | Seattle Sounders | 3:0 |
| 28.10.21 01:00 | New England Revolution | Colorado Rapids | 1:0 |
| 28.10.21 01:30 | Toronto FC | Philadelphia Union | 2:2 |
| 28.10.21 01:30 | Columbus Crew | Orlando City | 3:2 |
| 28.10.21 01:30 | Cincinnati FC | Nashville SC | 3:6 |
| 28.10.21 01:30 | Atlanta United FC | Inter Miami CF | 2:1 |
| 28.10.21 01:30 | D.C. United | New York Red Bulls | 1:0 |
| 28.10.21 01:30 | New York City FC | Chicago Fire | 1:0 |
| 28.10.21 02:00 | FC Dallas | Real Salt Lake | 1:2 |
| 28.10.21 02:30 | Sporting Kansas City | Los Angeles Galaxy | 2:0 |
| 28.10.21 04:00 | Portland Timbers | San Jose Earthquakes | 2:0 |
| 28.10.21 04:00 | Vancouver Whitecaps | Minnesota United FC | 2:1 |