| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 23.09.21 02:00 | Chicago Fire | New England Revolution | 2:3 |
| 30.10.21 19:30 | Inter Miami CF | New York City FC | 1:3 |
| 30.10.21 21:30 | Real Salt Lake | San Jose Earthquakes | 3:4 |
| 30.10.21 22:00 | New York Red Bulls | CF Montreal | 1:0 |
| 31.10.21 00:00 | Atlanta United FC | Toronto FC | 1:1 |
| 31.10.21 01:30 | D.C. United | Columbus Crew | 1:3 |
| 31.10.21 02:00 | FC Dallas | Austin FC | 2:1 |
| 31.10.21 18:00 | Minnesota United FC | Sporting Kansas City | 2:1 |
| 31.10.21 20:00 | Houston Dynamo | Colorado Rapids | 0:1 |
| 31.10.21 21:00 | Orlando City | Nashville SC | 1:1 |
| 01.11.21 00:30 | Philadelphia Union | Cincinnati FC | 2:0 |
| 02.11.21 03:00 | Seattle Sounders | Los Angeles Galaxy | 1:1 |
| 03.11.21 03:30 | Los Angeles FC | Vancouver Whitecaps | 1:1 |