| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 08.05.21 03:30 | Real Salt Lake | San Jose Earthquakes | 1:2 |
| 08.05.21 19:00 | New York Red Bulls | Toronto FC | 2:0 |
| 08.05.21 19:00 | Chicago Fire | Philadelphia Union | 0:2 |
| 08.05.21 19:30 | Columbus Crew | D.C. United | 3:1 |
| 08.05.21 19:30 | Nashville SC | New England Revolution | 2:0 |
| 08.05.21 21:00 | Vancouver Whitecaps | CF Montreal | 2:0 |
| 08.05.21 21:30 | FC Dallas | Houston Dynamo | 1:1 |
| 09.05.21 00:00 | Orlando City | New York City FC | 1:1 |
| 09.05.21 02:00 | Los Angeles Galaxy | Los Angeles FC | 2:1 |
| 09.05.21 04:00 | Colorado Rapids | Minnesota United FC | 3:2 |
| 09.05.21 19:00 | Inter Miami CF | Atlanta United FC | 1:1 |
| 10.05.21 01:30 | Sporting Kansas City | Austin FC | 2:1 |