| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 22.05.21 19:00 | CF Montreal | Cincinnati FC | 1:2 |
| 22.05.21 21:30 | Portland Timbers | Los Angeles Galaxy | 3:0 |
| 23.05.21 00:00 | Chicago Fire | Inter Miami CF | 1:0 |
| 23.05.21 01:00 | Orlando City | Toronto FC | 1:0 |
| 23.05.21 01:30 | New York City FC | Columbus Crew | 1:2 |
| 23.05.21 02:00 | New England Revolution | New York Red Bulls | 3:1 |
| 23.05.21 02:00 | FC Dallas | Real Salt Lake | 2:2 |
| 23.05.21 03:00 | Houston Dynamo | Vancouver Whitecaps | 2:1 |
| 23.05.21 04:00 | San Jose Earthquakes | Sporting Kansas City | 1:3 |
| 23.05.21 04:30 | Los Angeles FC | Colorado Rapids | 2:1 |
| 23.05.21 22:30 | Seattle Sounders | Atlanta United FC | 1:1 |
| 24.05.21 01:15 | D.C. United | Philadelphia Union | 0:1 |
| 24.05.21 03:00 | Nashville SC | Austin FC | 1:0 |