| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 29.05.21 19:00 | Chicago Fire | CF Montreal | 0:1 |
| 29.05.21 19:00 | New York Red Bulls | Orlando City | 2:1 |
| 29.05.21 21:00 | Columbus Crew | Toronto FC | 2:1 |
| 29.05.21 21:00 | Cincinnati FC | New England Revolution | 0:1 |
| 29.05.21 21:30 | Atlanta United FC | Nashville SC | 2:2 |
| 29.05.21 23:00 | Los Angeles FC | New York City FC | 1:2 |
| 30.05.21 01:00 | Los Angeles Galaxy | San Jose Earthquakes | 1:0 |
| 30.05.21 02:00 | Inter Miami CF | D.C. United | 0:3 |
| 30.05.21 02:30 | Sporting Kansas City | Houston Dynamo | 3:2 |
| 30.05.21 03:00 | Colorado Rapids | FC Dallas | 3:0 |
| 30.05.21 03:30 | Real Salt Lake | Minnesota United FC | 1:1 |
| 31.05.21 01:00 | Philadelphia Union | Portland Timbers | 3:0 |
| 31.05.21 03:30 | Seattle Sounders | Austin FC | 0:0 |