| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 19.06.21 02:00 | New York Red Bulls | Nashville SC | 2:0 |
| 19.06.21 04:00 | Real Salt Lake | Vancouver Whitecaps | 3:1 |
| 20.06.21 01:30 | New York City FC | New England Revolution | 2:3 |
| 20.06.21 01:30 | Columbus Crew | Chicago Fire | 2:0 |
| 20.06.21 01:30 | Cincinnati FC | Colorado Rapids | 0:2 |
| 20.06.21 01:30 | Toronto FC | Orlando City | 2:3 |
| 20.06.21 02:00 | D.C. United | Inter Miami CF | 1:0 |
| 20.06.21 02:30 | FC Dallas | Minnesota United FC | 1:1 |
| 20.06.21 03:00 | Los Angeles Galaxy | Seattle Sounders | 1:2 |
| 20.06.21 03:00 | Austin FC | San Jose Earthquakes | 0:0 |
| 20.06.21 04:30 | Portland Timbers | Sporting Kansas City | 2:1 |
| 20.06.21 05:00 | Los Angeles FC | Houston Dynamo | 1:1 |
| 20.06.21 20:00 | Atlanta United FC | Philadelphia Union | 2:2 |