| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 23.06.21 01:30 | Orlando City | San Jose Earthquakes | 5:0 |
| 24.06.21 01:00 | New England Revolution | New York Red Bulls | 3:2 |
| 24.06.21 01:30 | New York City FC | Atlanta United FC | 1:0 |
| 24.06.21 01:30 | Philadelphia Union | Columbus Crew | 1:0 |
| 24.06.21 02:00 | Minnesota United FC | Austin FC | 2:0 |
| 24.06.21 02:00 | Chicago Fire | Cincinnati FC | 0:1 |
| 24.06.21 02:00 | CF Montreal | D.C. United | 0:0 |
| 24.06.21 02:30 | Nashville SC | Toronto FC | 3:2 |
| 24.06.21 02:30 | Sporting Kansas City | Colorado Rapids | 3:1 |
| 24.06.21 02:30 | Houston Dynamo | Portland Timbers | 2:2 |
| 24.06.21 04:00 | Seattle Sounders | Real Salt Lake | 2:1 |
| 24.06.21 04:30 | Los Angeles FC | FC Dallas | 2:0 |
| 24.06.21 04:30 | Vancouver Whitecaps | Los Angeles Galaxy | 1:2 |