| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 12.11.21 02:20 | Miami Dolphins | Baltimore Ravens | 22:10 |
| 14.11.21 19:00 | New England Patriots | Cleveland Browns | 45:7 |
| 14.11.21 19:00 | Pittsburgh Steelers | Detroit Lions | 16:16OT |
| 14.11.21 19:00 | Indianapolis Colts | Jacksonville Jaguars | 23:17 |
| 14.11.21 19:00 | Tennessee Titans | New Orleans Saints | 23:21 |
| 14.11.21 19:00 | Dallas Cowboys | Atlanta Falcons | 43:3 |
| 14.11.21 19:00 | Washington Football Team | Tampa Bay Buccaneers | 29:19 |
| 14.11.21 19:00 | New York Jets | Buffalo Bills | 17:45 |
| 14.11.21 22:05 | Arizona Cardinals | Carolina Panthers | 10:34 |
| 14.11.21 22:05 | Los Angeles Chargers | Minnesota Vikings | 20:27 |
| 14.11.21 22:25 | Green Bay Packers | Seattle Seahawks | 17:0 |
| 14.11.21 22:25 | Denver Broncos | Philadelphia Eagles | 13:30 |
| 15.11.21 02:20 | Las Vegas Raiders | Kansas City Chiefs | 14:41 |
| 16.11.21 02:15 | San Francisco 49ers | Los Angeles Rams | 31:10 |