| Termin | Gospodarz | Gość | Wynik |
|---|---|---|---|
| 15.10.21 02:20 | Philadelphia Eagles | Tampa Bay Buccaneers | 22:28 |
| 17.10.21 15:30 | Jacksonville Jaguars | Miami Dolphins | 23:20 |
| 17.10.21 19:00 | Carolina Panthers | Minnesota Vikings | 28:34OT |
| 17.10.21 19:00 | Baltimore Ravens | Los Angeles Chargers | 34:6 |
| 17.10.21 19:00 | Chicago Bears | Green Bay Packers | 14:24 |
| 17.10.21 19:00 | Detroit Lions | Cincinnati Bengals | 11:34 |
| 17.10.21 19:00 | Indianapolis Colts | Houston Texans | 31:3 |
| 17.10.21 19:00 | New York Giants | Los Angeles Rams | 11:38 |
| 17.10.21 19:00 | Washington Football Team | Kansas City Chiefs | 13:31 |
| 17.10.21 22:05 | Cleveland Browns | Arizona Cardinals | 14:37 |
| 17.10.21 22:25 | New England Patriots | Dallas Cowboys | 29:35OT |
| 17.10.21 22:25 | Denver Broncos | Las Vegas Raiders | 24:34 |
| 18.10.21 02:20 | Pittsburgh Steelers | Seattle Seahawks | 23:20OT |
| 19.10.21 02:15 | Tennessee Titans | Buffalo Bills | 34:31 |